Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease
β Scribed by U. HINDORF; M. JOHANSSON; A. ERIKSSON; E. KVIFORS; S. H. C. ALMER
- Book ID
- 108605551
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 148 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0269-2813
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## Background: 6-mercaptopurine (6-mp) and its prodrug azathioprine (aza) are effective for the induction and maintenance of remission and reduction of corticosteroid exposure for pediatric inflammatory bowel disease (ibd). the standard dose of 6-mp is 1.0-1.5 mg/kg/day and for aza is 2.0-2.5 mg/kg
Background: Nodular regenerative hyperplasia (NRH) is a rare hepatic disorder that may lead to severe portal hypertension. Cases of NRH have been reported in patients receiving thiopurines for inflammatory bowel disease (IBD). Since azathioprine (AZA) is used more and more frequently as a maintenanc