𝔖 Bobbio Scriptorium
✦   LIBER   ✦

SH2 domain binding to phosphopeptide ligands: potential for drug targeting

✍ Scribed by Kasembeli, Moses, M.


Book ID
111656656
Publisher
Frontiers in BioScience
Year
2009
Tongue
English
Weight
284 KB
Volume
Volume
Category
Article
ISSN
1093-9946

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Phosphopeptide Ligands of the SHP-1 N-SH
✍ Kornelia Hampel; Ina Kaufhold; Martin Zacharias; Frank D. Böhmer; Diana Imhof 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 424 KB 👁 1 views

## Abstract Src homology 2 (SH2)‐domain‐mediated interactions with phosphotyrosine (pY)‐containing ligands are critical for the regulation of SHP‐1 phosphatase activity. Peptides based on a binding site from receptor tyrosine kinase Ros (EGLN‐pY2267‐MVL, 1) have recently been shown to bind to the S

Quantum mechanical binding free energy c
✍ Victor M. Anisimov; Claudio N. Cavasotto 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB

## Abstract The accurate and efficient calculation of binding free energies is essential in computational biophysics. We present a linear‐scaling quantum mechanical (QM)‐based end‐point method termed MM/QM‐COSMO to calculate binding free energies in biomolecular systems, with an improved descriptio