SH2 domain binding to phosphopeptide ligands: potential for drug targeting
✍ Scribed by Kasembeli, Moses, M.
- Book ID
- 111656656
- Publisher
- Frontiers in BioScience
- Year
- 2009
- Tongue
- English
- Weight
- 284 KB
- Volume
- Volume
- Category
- Article
- ISSN
- 1093-9946
- DOI
- 10.2741/3292
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Src homology 2 (SH2)‐domain‐mediated interactions with phosphotyrosine (pY)‐containing ligands are critical for the regulation of SHP‐1 phosphatase activity. Peptides based on a binding site from receptor tyrosine kinase Ros (EGLN‐pY2267‐MVL, 1) have recently been shown to bind to the S
## Abstract The accurate and efficient calculation of binding free energies is essential in computational biophysics. We present a linear‐scaling quantum mechanical (QM)‐based end‐point method termed MM/QM‐COSMO to calculate binding free energies in biomolecular systems, with an improved descriptio