ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain

Switching between low and high affinity

Switching between low and high affinity for the Syk tandem SH2 domain by irradiation of azobenzene containing ITAM peptidomimetics

✍ Joeri Kuil; Loek T.M. van Wandelen; Nico J. de Mol; Rob M.J. Liskamp 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB

## Abstract Spleen tyrosine kinase (Syk) plays an essential role in IgE receptor signaling (FcεRI), which leads to mast cell degranulation. Divalent binding of the tandem SH2 domain (tSH2) of Syk to the intracellular ITAM motif of FcεRI activates the kinase domain of Syk, and thereby initiates cell