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SH2 and SH3 domains: Potential targets for anti-cancer drug design

โœ Scribed by Thomas E. Smithgall


Book ID
113409944
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
990 KB
Volume
34
Category
Article
ISSN
1056-8719

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๐Ÿ“œ SIMILAR VOLUMES


SH3 domains and drug design: Ligands, st
โœ D. C. Dalgarno; M. C. Botfield; R. J. Rickles ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 567 KB

The ligand binding preferences, structural features, and biological function of SH3 (Src homology 3) domains are discussed. SH3 domains bind ''core'' Pro-rich peptide ligands (7-9 amino acids in length) in a polyproline II helical conformation in a highly conserved aromatic rich patch on the protein