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Synthesis and evaluation of phosphopeptides containing iminodiacetate groups as binding ligands of the Src SH2 domain

✍ Scribed by Guofeng Ye; Aaron D. Schuler; Yousef Ahmadibeni; Joel R. Morgan; Absar Faruqui; Kezhen Huang; Gongqin Sun; John A. Zebala; Keykavous Parang


Book ID
118426504
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
999 KB
Volume
37
Category
Article
ISSN
0045-2068

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Phosphopeptide Ligands of the SHP-1 N-SH
✍ Kornelia Hampel; Ina Kaufhold; Martin Zacharias; Frankβ€…D. BΓΆhmer; Diana Imhof πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 424 KB πŸ‘ 1 views

## Abstract Src homologyβ€…2 (SH2)‐domain‐mediated interactions with phosphotyrosine (pY)‐containing ligands are critical for the regulation of SHP‐1 phosphatase activity. Peptides based on a binding site from receptor tyrosine kinase Ros (EGLN‐pY2267‐MVL, 1) have recently been shown to bind to the S