Evaluation of the Carbohydrate Recognition Domain of the Bacterial Adhesin FimH: Design, Synthesis and Binding Properties of Mannoside Ligands.

ChemInform Abstract: Design and Synthesi

ChemInform Abstract: Design and Synthesis of SH3 Domain Binding Ligands: Modifications of the Consensus Sequence XPpXP.

✍ David J. Witter; Sara J. Famiglietti; John C. Cambier; Arlindo L. Castelhano 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Design and Synthesis of SH3 Domain Binding Ligands: Modifications of the Consensus Sequence XPpXP. -The synthesized spirolactams (VIII) and (XI) are incorporated in a nonapeptide sequence, leading to effective ligands of SH3 domains. The stereochemistry of (VIII) and (XI) is not determined. -(WITTER