ChemInform Abstract: Design and Synthesis of SH3 Domain Binding Ligands: Modifications of the Consensus Sequence XPpXP.

✍ Scribed by David J. Witter; Sara J. Famiglietti; John C. Cambier; Arlindo L. Castelhano

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199911162

✦ Synopsis

Design and Synthesis of SH3 Domain Binding Ligands: Modifications of the Consensus Sequence XPpXP. -The synthesized spirolactams (VIII) and (XI) are incorporated in a nonapeptide sequence, leading to effective ligands of SH3 domains. The stereochemistry of (VIII) and (XI) is not determined. -(WITTER,