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Synthesis and evaluation of conformationally constrained peptide analogues as the Src SH3 domain binding ligands

โœ Scribed by Rakesh Tiwari; Alex Brown; Seetha Narramaneni; Gongqin Sun; Keykavous Parang


Book ID
116309179
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
491 KB
Volume
92
Category
Article
ISSN
0300-9084

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Design and Synthesis of SH3 Domain Binding Ligands: Modifications of the Consensus Sequence XPpXP. -The synthesized spirolactams (VIII) and (XI) are incorporated in a nonapeptide sequence, leading to effective ligands of SH3 domains. The stereochemistry of (VIII) and (XI) is not determined. -(WITTER