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Serum heme-albumin: An allosteric protein

✍ Scribed by Paolo Ascenzi; Mauro Fasano

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 130 KB
Volume: 61
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.263

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✦ Synopsis

Abstract

Heme scavenging by plasma proteins, including serum albumin (SA), provides protection against free‐heme oxidative damage, limits access by pathogens to the heme, and contributes to iron homeostasis by recycling the heme iron. In turn, serum heme‐albumin (SA‐heme) acquires heme‐based ligand‐binding and (pseudo‐)enzymatic properties. Heme binding to SA and SA‐heme reactivity are allosterically and competitively modulated by endogenous and exogenous third components, this being relevant in pharmacotherapy management. © 2009 IUBMB IUBMB Life, 61: 1118–1122, 2009

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