𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Serum DNA binding activity in healthy subjects and in rheumatic disease

✍ Scribed by Peter Hasselbacher; E. Carwile LeRoy

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
466 KB
Volume
17
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Modifications of the Farr ammonium sulfate precipitation assay for DNA antibodies have increased sensitivity and led to the detection of DNA binding in the sera of healthy subjects and subjects with rheumatic disease other than systemic lupus erythematosus (SLE). The presence of binding in immunochemically pure IgG and the pattern of inhibition by native and denatured DNA support the thesis that DNA binding of normal, non‐SLE, and SLE sera is antibody and similar in kind although not in degree. The presence of antibodies to DNA in normal and non‐SLE sera may limit the qualitative role of these antibodies in SLE and render DNA antibodies similar to antiglobulin and other antinuclear antibodies in rheumatic disease.

πŸ“œ SIMILAR VOLUMES

Serum antioxidant capacity in healthy an
Serum antioxidant capacity in healthy and diabetic subjects as determined by enhanced chemiluminescence
✍ Pinzani, Pamela ;Petruzzi, Enrico ;Orlando, Claudio ;Gallai, Roberta ;Serio, Mar πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons βš– 64 KB πŸ‘ 1 views

Free radicals are considered to be important factors involved in many physiopathological processes. Several methods have been proposed for studying the mechanisms of antioxidant protection against free radical-induced injury, including the measurement of the total antioxidant capacity (TAC) in body

Kinetic modeling of benzodiazepine recep
Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects
✍ J. Douglas Bremner; Andrew Horti; Lawrence H. Staib; Yolanda Zea-Ponce; Robert S πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 187 KB πŸ‘ 2 views

Quantitation of the PET benzodiazepine receptor antagonist, [ 11 C]Iomazenil, using low specific activity radioligand was recently described. The purpose of this study was to quantitate benzodiazepine receptor binding in human subjects using PET and high specific activity [ 11 C]Iomazenil. Six healt

Psychologically meaningful activity, ill
Psychologically meaningful activity, illness intrusiveness, and quality of life in rheumatic diseases
✍ Devins, Gerald M. πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 43 KB πŸ‘ 2 views

Chronic disabling disease compromises quality of life. Among the factors most widely recognized as responsible for such effects among people with rheumatic conditions are pain, disability, and a host of ensuing psychological changes (e.g., helplessness, hopelessness, and depression). Disease and dis