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Circadian variation in O6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects

✍ Scribed by Cécile Marchenay; Eric Cellarier; Francis Lévi; Christine Rolhion; Fabrice Kwiatkowski; Bruno Claustrat; Jean-Claude Madelmont; Philippe Chollet

Publisher: John Wiley and Sons
Year: 2000
Tongue: French
Weight: 169 KB
Volume: 91
Category: Article
ISSN: 0020-7136
DOI: 10.1002/1097-0215(20010101)91:1<60::aid-ijc1010>3.0.co;2-n

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O 6 -Alkylguanine-DNA-alkyltransferase (ATase) is an important modulator of alkylating agent-induced toxicity and carcinogenicity, but those factors which influence the expression of this repair protein in human tissues are poorly characterised. In this study, we have determined ATase levels in macr