## Abstract ## Objective To describe the clinical and laboratory features and natural history of the disease in systemic sclerosis (SSc; scleroderma) patients with anti–topoisomerase I (anti–topo I) antibody who have different skin thickness progression rates (STPRs). ## Methods SSc patients (n
Correlation of serum anti-DNA topoisomerase I antibody levels with disease severity and activity in systemic sclerosis
✍ Scribed by Paul Q. Hu; Noreen Fertig; Thomas A. Medsger Jr.; Timothy M. Wright
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 147 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Objective Fibroblasts play a crucial role in the development of systemic sclerosis (SSc), and antifibroblast antibodies (AFAs) capable of inducing a proinflammatory phenotype in fibroblasts have been detected in the sera of SSc patients. This study examined the prevalence of AFAs in
A Report of Two Cases MASATAKA KUWANA, TAKA0 FUJII, TSUNEYO MIMORI, and JUNICHI KABURAKI Anti-DNA topoisomerase I (anti-topo I) antibody profiles were compared before and after lung cancer in 2 patients with systemic sclerosis (SSc). Both patients developed adenocarcinoma of the lung late in the cou