DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti–topoisomerase I autoantibodies from systemic sclerosis patients

Direct binding of anti–DNA topoisomerase

Direct binding of anti–DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis

✍ Jill Hénault; Mélanie Tremblay; Isabelle Clément; Yves Raymond; Jean-Luc Senécal 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB 👁 1 views

## Abstract ## Objective Fibroblasts play a crucial role in the development of systemic sclerosis (SSc), and antifibroblast antibodies (AFAs) capable of inducing a proinflammatory phenotype in fibroblasts have been detected in the sera of SSc patients. This study examined the prevalence of AFAs in