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Separation and determination of saturated and unsaturated fatty acids by means of the lead salt-ether method

✍ Scribed by Walter F. Baughman; George S. Jamieson

Publisher
Elsevier Science
Year
1922
Tongue
English
Weight
125 KB
Volume
194
Category
Article
ISSN
0016-0032

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✦ Synopsis

THE reaction to strychnine of the very young rat is not unlike that shown by animals lower than mammals.

This prototype reaction may be considered as functional evidence of the phylogeny of the nervous system. Very young rats also have a relatively high natal resistance to the action of strychnine which declines as the animals grow older until they reach a certain age. These observations agree with many scattering data on other animals, including man.

After the decline in natal resistance, the rat develops a postnatal resistance.

Those animals for which sufficient data regarding the toxicity of strychnine exist showed this curious coincidence-a post-natal resistance to strychnine was developed in those animals in which the pyramidal tract is in the dorsal funiculus, while such resistance was not developed in animals having the pyramidal tract in the lateral funiculus.

The data were not sufficient to permit analysis of cases where the pyramidal tract is in the ventral funiculus.

The observations suggest that strychnine tests would be useful, particularly in conjunction with other methods, in studying functional development of the central nervous system. SEPARATION AND DETERMINATION OF SATURATED AND UNSATURATED FATTY ACIDS BY MEANS OF THE LEAD SALT-ETHER METHOD.'

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