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Self-Consistent Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C via Controlled Oligomerization

โœ Scribed by Nicewicz, David A.; Satterfield, Andrew D.; Schmitt, Daniel C.; Johnson, Jeffrey S.

Book ID
115314156
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
697 KB
Volume
130
Category
Article
ISSN
0002-7863

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โœ C.H. Kuo; S.P. Plevyak; T. Biftu; W.H. Parsons; G.D. Berger ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 258 KB

The title compound and its Cdpivaloyloxy methyl (PGM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6. Subsequent radical deoxygcnation via the Barton-McCombie procedure. followed by dqnvtection, affarded the product 11