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Asymmetric Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C

โœ Scribed by Evans, David A.; Barrow, James C.; Leighton, James L.; Robichaud, Albert J.; Sefkow, Michael


Book ID
125942068
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
264 KB
Volume
116
Category
Article
ISSN
0002-7863

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The synthesis of C3-methyl, C3-decarboxy
โœ C.H. Kuo; S.P. Plevyak; T. Biftu; W.H. Parsons; G.D. Berger ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 258 KB

The title compound and its Cdpivaloyloxy methyl (PGM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6. Subsequent radical deoxygcnation via the Barton-McCombie procedure. followed by dqnvtection, affarded the product 11