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Absolute Stereochemistry of the Squalene Synthase Inhibitor Zaragozic Acid C

โœ Scribed by Santini, Conrad; Ball, Richard G.; Berger, Gregory D.


Book ID
127142240
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
794 KB
Volume
59
Category
Article
ISSN
0022-3263

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The title compound and its Cdpivaloyloxy methyl (PGM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6. Subsequent radical deoxygcnation via the Barton-McCombie procedure. followed by dqnvtection, affarded the product 11