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SELECTIVITY RELEASE OF THE TYPE II DECOY IL-1 RECEPTOR

✍ Scribed by Simone Orlando; Nadia Polentarutti; Alberto Mantovani

Book ID
115596430
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
185 KB
Volume
12
Category
Article
ISSN
1043-4666

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✍ Natacha Bessis; Laurence GuΓ©ry; Alberto Mantovani; Annunciata Vecchi; John E. Si πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 129 KB πŸ‘ 1 views

IL-1 is a key cytokine involved in the inflammatory response. The type II receptor of IL-1 (IL-1RII) acts as a decoy receptor, binding and inhibiting the effect of IL-1. This study was undertaken to establish whether IL-1RII can ameliorate collagen-induced arthritis, a model of inflammatory arthriti