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Overexpression of the IL-1 type II decoy receptor inhibits IL-1 activities

โœ Scribed by F. Colotta; M. Sironi; F. Re; N. Polentarutti; A. Mantovani

Book ID
116172577
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
147 KB
Volume
6
Category
Article
ISSN
1043-4666

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โœ Natacha Bessis; Laurence Guรฉry; Alberto Mantovani; Annunciata Vecchi; John E. Si ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 129 KB ๐Ÿ‘ 1 views

IL-1 is a key cytokine involved in the inflammatory response. The type II receptor of IL-1 (IL-1RII) acts as a decoy receptor, binding and inhibiting the effect of IL-1. This study was undertaken to establish whether IL-1RII can ameliorate collagen-induced arthritis, a model of inflammatory arthriti