𝔖 Bobbio Scriptorium
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Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein

✍ Scribed by C. B. Eap; C. Cuendet; P. Baumann

Book ID
112275564
Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
672 KB
Volume
337
Category
Article
ISSN
0028-1298

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A novel probe was developed to measure drug association with the F1\*S variant of the human serum protein alpha 1-acid glycoprotein (AGP). The molecule 2hydroxy-3,5-diiodo-N-[2(diethylamino)ethyl]benzamide (DEDIC) binds to AGP, quenching its native ¯uorescence. This quenching was ®tted to a two-site