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Selective binding of imatinib to the genetic variants of human α1-acid glycoprotein

✍ Scribed by Ilona Fitos; Júlia Visy; Ferenc Zsila; György Mády; Miklós Simonyi

Book ID
116271722
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
772 KB
Volume
1760
Category
Article
ISSN
0304-4165

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Human alpha(1)-acid glycoprotein (AGP), a major carrier of many basic drugs in circulation, consists of at least two genetic variants, namely A and F1\*S variant. Interestingly, the variants of AGP have different drug-binding properties. The purpose of this study was to identify the amino acid resid