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Specific ligand binding on genetic variants of human α1-acid glycoprotein studied by circular dichroism spectroscopy

✍ Scribed by Ilona Fitos; Júlia Visy; Ferenc Zsila; Zsolt Bikádi; György Mády; Miklós Simonyi


Book ID
113486981
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
244 KB
Volume
67
Category
Article
ISSN
0006-2952

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Human alpha(1)-acid glycoprotein (AGP), a major carrier of many basic drugs in circulation, consists of at least two genetic variants, namely A and F1\*S variant. Interestingly, the variants of AGP have different drug-binding properties. The purpose of this study was to identify the amino acid resid