A site-directed mutagenesis study of dru
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Koji Nishi; Megumi Ueno; Yuka Murakami; Naoko Fukunaga; Teruo Akuta; Daisuke Kad
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Article
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2009
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John Wiley and Sons
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English
⚖ 205 KB
Human alpha(1)-acid glycoprotein (AGP), a major carrier of many basic drugs in circulation, consists of at least two genetic variants, namely A and F1\*S variant. Interestingly, the variants of AGP have different drug-binding properties. The purpose of this study was to identify the amino acid resid