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Selective binding interactions of deramciclane to the genetic variants of human α1-acid glycoprotein

✍ Scribed by Ilona Fitos; Júlia Visy; Miklós Simonyi; György Mády; Ferenc Zsila


Book ID
116272136
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
963 KB
Volume
1800
Category
Article
ISSN
0304-4165

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Human alpha(1)-acid glycoprotein (AGP), a major carrier of many basic drugs in circulation, consists of at least two genetic variants, namely A and F1\*S variant. Interestingly, the variants of AGP have different drug-binding properties. The purpose of this study was to identify the amino acid resid