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Selective inhibitors of type I receptor kinase block cellular transforming growth factor-β signaling

✍ Scribed by Rongrong Ge; Vaishali Rajeev; Gayathri Subramanian; Kim A Reiss; David Liu; Linda Higgins; Alison Joly; Sundeep Dugar; Jit Chakravarty; Margaret Henson; Glenn McEnroe; George Schreiner; Michael Reiss


Book ID
113487156
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
386 KB
Volume
68
Category
Article
ISSN
0006-2952

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## Abstract ## Objective Members of the transforming growth factor β (TGFβ) cytokine superfamily play critical roles in both homeostasis and disease. In light of their profibrotic effects, these molecules are implicated in the pathogenesis of fibrosis. In fibroblasts, TGFβ signals through the acti