𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Type II Receptor Kinase and Mixed Lineage Kinase-7

✍ Scribed by Li, Hong-yu; Wang, Yan; Heap, Charles R.; King, Chi-Hsin R.; Mundla, Sreenivasa R.; Voss, Matthew; Clawson, David K.; Yan, Lei; Campbell, Robert M.; Anderson, Bryan D.; Wagner, Jill R.; Britt, Karen; Lu, Ku X.; McMillen, William T.; Yingling, Jonathan M.

Book ID
124160812
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
104 KB
Volume
49
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

An increased transforming growth factor
An increased transforming growth factor β receptor type I:Type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor β receptor type II in scleroderma
✍ Jaspreet Pannu; Elizabeth Gore-Hyer; Masayoshi Yamanaka; Edwin A. Smith; Semyon 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 545 KB

## Abstract ## Objective Aberrant transforming growth factor β (TGFβ) signaling has been implicated in the pathogenesis of scleroderma (systemic sclerosis [SSc]), but the contribution of specific components in this pathway to SSc fibroblast phenotype remains unclear. This study was undertaken to d