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Contribution of activin receptor–like kinase 5 (transforming growth factor β receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts

✍ Scribed by Yunliang Chen; Xu Shi-Wen; Mark Eastwood; Carol M. Black; Christopher P. Denton; Andrew Leask; David J. Abraham


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
513 KB
Volume
54
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Members of the transforming growth factor β (TGFβ) cytokine superfamily play critical roles in both homeostasis and disease. In light of their profibrotic effects, these molecules are implicated in the pathogenesis of fibrosis. In fibroblasts, TGFβ signals through the acti