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Selective expression of LDLR and VLDLR in myelinating oligodendrocytes

โœ Scribed by Shufang Zhao; Xuemei Hu; Jinsil Park; Ying Zhu; Qiang Zhu; Hong Li; Chen Luo; Ruifa Han; Nigel Cooper; Mengsheng Qiu

Book ID
111700084
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
265 KB
Volume
236
Category
Article
ISSN
1058-8388

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The proteolipid proteins play a major role in the structure of the CNS myelin sheath, but they have also been implicated in the oligodendrocyte development leading to myelination. Mutations in the PLP gene result in severe dysmyelination and a paucity of mature oligodendrocytes. The myelin deficient