Down-regulation of myelin-gene expression in oligodendrocytes by axonal withdrawal
โ Scribed by Goto, Kaoru; Kurihara, Tadashi; Takahashi, Yasuo; Kondo, Hisatake
- Book ID
- 122878186
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 119 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0921-8696
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The myelin proteolipid protein (Plp) gene is expressed in oligodendrocytes and encodes the most abundant protein (approximately 50%) present in mature myelin from the central nervous system (CNS). Plp gene activity is low to nonexistent early in development but sharply increases, concurrently with t
Myelin gene expression (Po, MBP, P,, and MAG) was investigated during Wallerian degeneration and in the presence or absence of subsequent axonal regeneration and remyelination. The steady state levels of mRNA and protein were assessed in the crushed or permanently transected rat sciatic nerve at 0,