𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Sedative activity in mice of a hydroalcohol extract of Hypericum perforatum L.

✍ Scribed by Mihaela Gîrzu; Andrée Carnat; Anne-Marie Privat; Joseph Fialip; André-Paul Carnat; Jean-Louis Lamaison

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
53 KB
Volume
11
Category
Article
ISSN
0951-418X

No coin nor oath required. For personal study only.

✦ Synopsis

The sedative activity of a hydroalcohol extract of Hypericum perforatum L. (Hypericaceae) and some of its isolated constituents was evaluated in mice. A dry hydroalcohol extract, orally administered at 26.5 mg/kg, induced a marked sedation as measured by two different tests (actimeter and sleep potentiation), compared with controls (diazepam, 2 mg/kg, per os). Several fractions were isolated from this hydroalcohol extract: hypericin, flavones, butanol fraction, aqueous fraction; a separation and purification method was developed for hypericin. None of the isolated fractions exhibited the same sedative activity as the hydroalcohol extract.

📜 SIMILAR VOLUMES

Antiviral In vitro activity of Hypericum
Antiviral In vitro activity of Hypericum perforatum l. extract on the human cytomegalovirus (HCMV)
✍ S. Axarlis; A. Mentis; C. Demetzos; S. Mitaku; A. L. Skaltsounis; M. Marselos; M 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 2 views

The total methanol extract and chromatographic fractions of the extract of the aerial parts of Hypericum perforatum L. were investigated for their antiviral activity against human cytomegalovirus (HCMV) AD-169 laboratory strain by modification of the widely used diagnostic method 'shell-vial' cultur

A comprehensive study of extraction of h
A comprehensive study of extraction of hyperoside from Hypericum perforatum L. using CTAB reverse micelles
✍ Xiaohua Zhou; Lichun Dong; Duanhua Li 📂 Article 📅 2008 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 256 KB 👁 1 views

## Abstract **BACKGROUND:** Hyperoside is a valuable natural pharmaceutical that has many biomedical functions. By the traditional method of alcohol extraction, only hyperoside solution of very low concentration can be obtained, so a new method is urgently needed to produce pure hyperoside more eff

Effects of Hypericum calycinum L. Extrac
Effects of Hypericum calycinum L. Extract on the Central Nervous System in Mice
✍ Yusuf Öztürk; Süleyman Aydin; Rana Beis; K. Hüsnü Can Başer; Hülya Berberoğlu 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 340 KB 👁 2 views

Hypericum species have been used as herbal remedies for the therapy of various neurological disorders. In the present study, the efTects of Hypericum culycinum on the central nervous system were investigated using various behavioural models including swimming time, locomotor activity, tail-flick and

Successful treatment of collagen-induced
Successful treatment of collagen-induced arthritis in mice with a hydroalcohol extract of seeds of Pterodon pubescens
✍ K. C. C. Sabino; F. A. Castro; J. C. R. Oliveira; S. R. A. Dalmau; M. G. P. Coel 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 54 KB 👁 2 views

The antiarthritic effect of a hydroalcohol extract of Pterodon pubescens (HEPp) seeds was tested using collagen-induced arthritis (CIA) in DBA1/J mice treated with daily oral doses of HEPp in different schedules. The preventive treatment significantly reduced both the arthritic index (AI) and the CI

Antidiarrhoeal Activity of Hamelia paten
Antidiarrhoeal Activity of Hamelia patens Methanol Extract in Rats and Mice
✍ Salud Pérez G.; Miguel A. Zavala S.; Rosario Vargas S.; Edgar Hernández Z.; Rosa 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB 👁 1 views

The inhibitory action of Hamelia patens methanol extract was studied in vitro on uterus, ileum and duodenum, and the antidiarrhoeal activity was evaluated in vivo on mice and rats. It was found that for the uterus and intestine the inhibitory response was dose dependent and the major antidiarrhoeal

Conditional activation of a single-copy
Conditional activation of a single-copy L1 transgene in mice by Cre
✍ Wenfeng An; Jeffrey S. Han; Christina M. Schrum; Anirban Maitra; Frank Koentgen; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 584 KB

## Abstract The synthetic L1 retrotransposon, __ORFeus__, is useful for probing mechanisms of L1 retrotransposition in vivo and for genome‐wide mouse mutagenesis because of its high level of activity. To achieve controlled activation of __ORFeus__ in mice, we constructed __ORFeus^LSL^__, in which _