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Successful treatment of collagen-induced arthritis in mice with a hydroalcohol extract of seeds of Pterodon pubescens

✍ Scribed by K. C. C. Sabino; F. A. Castro; J. C. R. Oliveira; S. R. A. Dalmau; M. G. P. Coelho

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
54 KB
Volume
13
Category
Article
ISSN
0951-418X

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✦ Synopsis

The antiarthritic effect of a hydroalcohol extract of Pterodon pubescens (HEPp) seeds was tested using collagen-induced arthritis (CIA) in DBA1/J mice treated with daily oral doses of HEPp in different schedules. The preventive treatment significantly reduced both the arthritic index (AI) and the CIA incidence. Using a therapeutic protocol, only the lower dose of HEPp induced a decrease in both parameters. These results provide a scientific foundation for the popular use of Pp seed infusions in rheumatoid arthritis (RA) treatment.

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