Secondary acute leukemia and myelodysplastic syndrome with 11q23 abnormalities
β Scribed by Secker-Walker, L M; Moorman, A V; Bain, B J; Mehta, A B
- Book ID
- 110053845
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 47 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0887-6924
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We have identified a novel fusion partner of __MLL__, namely the mastermind like 2 (__MAML____2__ gene), in secondary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with inv(11)(q21q23). RTβPCR and sequencing revealed that exon 7 of __MLL__ was fused to exon 2 of __MAML
## Abstract Among 511 patients with therapyβrelated myelodysplastic syndrome or acute leukemia (tβMDS/tβAL) and balanced chromosome aberrations, 162 (32%) had translocations involving 11q23. The recurring translocation partners were 9p22 (48%), 19p13.3 (11%), 19p13.1 (10%), 4q21 (9%), 6q27 (6%), 1p