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Secondary acute myelogenous leukemia and myelodysplasia without abnormalities of chromosome 11q23 following treatment of acute leukemia with topoisomerase II-based chemotherapy

✍ Scribed by Seiter, K; Feldman, E J; Sreekantaiah, C; Pozzuoli, M; Weisberger, J; Liu, D; Papageorgio, C; Weiss, M; Kancherla, R; Ahmed, T


Book ID
110054890
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
101 KB
Volume
15
Category
Article
ISSN
0887-6924

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Identification of a novel fusion gene ML
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## Abstract We have identified a novel fusion partner of __MLL__, namely the mastermind like 2 (__MAML____2__ gene), in secondary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with inv(11)(q21q23). RT‐PCR and sequencing revealed that exon 7 of __MLL__ was fused to exon 2 of __MAML

Clinical and biological characteristics