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Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation

✍ Scribed by Hisamichi Tauchi; Daisuke Tomizawa; Mariko Eguchi; Minenori Eguchi-Ishimae; Katsuyoshi Koh; Masahiro Hirayama; Noriko Miyamura; Naoko Kinukawa; Yasuhide Hayashi; Keizo Horibe; Eiichi Ishii

Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 222 KB
Volume: 32
Category: Article
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2008.03.018

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Chromosomal analysis of acute monocytic leukemia cells in a female infant revealed a t(6;11)(q27;q23) translocation. Southern blot analysis with a cDNA probe of the MLL gene at chromosome band 11q23 indicated that the breakpoint was in an 8.3-kb BamHI fragment that contained exons 5-11 of the MLL ge