Screening of some African medicinal plants for antiulcerogenic activity: Part 1

✍ Scribed by Paul V. Tan; Clarisse K. Njimi; Johnson F. Ayafor

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 81 KB
• Volume: 11
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199702)11:1<45::aid-ptr945>3.0.co;2-i

✦ Synopsis

Aqueous extracts of six plant species used in

Cameroonian ethnomedicine for the relief of stomach complaints were tested for antiulcer activity. An HCl/EtOH solution was used to induce gastric lesions in male Wistar rats (140-190 g). The extracts of Voacanga africana, Eremomastax speciosa, Emilia praetermissa, Spilanthes filicaulis and Centella asiatica produced complete mucosal cytoprotection at a dose of 1000, 190, 500, 2000 and 500 mg/kg respectively. The extract of Clerodendrum splendens (500, 750, 1000 mg/kg) showed significant (p < 0.01) dosedependent cytoprotection (50%-75%) compared with the controls. A combination of C. asiastica and S. filicaulis (1:1) (250-500 mg/kg) did not reveal the therapeutic advantage of combining both plant extracts in the clinical management of stomach ulcers.