Screening of Traditional Medicines for their Inhibitory Activity Against HIV-1 Protease
✍ Scribed by Hong-Xi Xu; Min Wan; Boon-Nee Loh; Oi-Lian Kon; Peng-Wai Chow; Keng-Yeow Sim
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 312 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
Aqueous extracts of 75 different traditional medicines, currently used for the treatment of various human diseases in China, Japan and Indonesia, were screened for possible inhibitory activity against HIV-1 protease using fluorogenic assay. Forty extracts exhibited inhibitory activity at a concentration of 250 pg/mL, and 18 of them inhibited HIV-1 protease activity by more than 70%. Among the extracts examined, B e h c a n d a chinensis, Magnolia fargesii, Paeonia suffruticosa, Phellodendron amurense and Terminalia chebula were also effective at a concentration of 25 +g/mL in the Ruorogenic assay.