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Screening for RAD51 and BRCA2 BRC repeat mutations in breast and ovarian cancer families

✍ Scribed by Katrin Rapakko; Katri Heikkinen; Sanna-Maria Karppinen; Robert Winqvist


Book ID
116333815
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
99 KB
Volume
236
Category
Article
ISSN
0304-3835

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There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations, and whether they are associated with a particular clinical phenotype, remains unclear. Resolving these questions has important implications