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Screening for hereditary colorectal cancer

✍ Scribed by H.F.A. Vasen; J-P. Mecklin; P.Meera Khan; H.T. Lynch

Book ID
118556758
Publisher
The Lancet
Year
1994
Tongue
English
Weight
194 KB
Volume
344
Category
Article
ISSN
0140-6736

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Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, caused by germline mutations in DNA mismatch-repair genes (MMR). These mutations lead to microsatellite instability (MSI). It has been found that the MSI is not confined to the setting of hereditary disease and may