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Microsatellite screening for hereditary nonpolyposis colorectal cancer is cost-effective

✍ Scribed by Gabriela Moeslein


Book ID
111725112
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
58 KB
Volume
6
Category
Article
ISSN
1462-9410

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Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, caused by germline mutations in DNA mismatch-repair genes (MMR). These mutations lead to microsatellite instability (MSI). It has been found that the MSI is not confined to the setting of hereditary disease and may

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## Background: Germline mutations in the dna mismatch repair genes, msh2, mlh1, and others are associated with hereditary nonpolyposis colorectal cancer (hnpcc). due to the high costs of sequencing, cheaper screening methods are needed to identify hnpcc cases. ideally, these methods should have a h