Microsatellite screening for hereditary nonpolyposis colorectal cancer is cost-effective
β Scribed by Gabriela Moeslein
- Book ID
- 111725112
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 58 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1462-9410
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Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, caused by germline mutations in DNA mismatch-repair genes (MMR). These mutations lead to microsatellite instability (MSI). It has been found that the MSI is not confined to the setting of hereditary disease and may
## Background: It has been estimated that the prevalence of carriers of a mutated mismatch repair (mmr) gene among the general population in western countries is between 5 and 50 per 10,000. these carriers have a risk of >85% of developing colorectal carcinoma (crc) and therefore need careful follo
## Background: Germline mutations in the dna mismatch repair genes, msh2, mlh1, and others are associated with hereditary nonpolyposis colorectal cancer (hnpcc). due to the high costs of sequencing, cheaper screening methods are needed to identify hnpcc cases. ideally, these methods should have a h