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Aggressive polyps in hereditary nonpolyposis colorectal cancer: Targets for screening

✍ Scribed by David A. Ahlquist

Book ID
118882076
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
301 KB
Volume
108
Category
Article
ISSN
0016-5085

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Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, caused by germline mutations in DNA mismatch-repair genes (MMR). These mutations lead to microsatellite instability (MSI). It has been found that the MSI is not confined to the setting of hereditary disease and may