Molecular screening for hereditary nonpo
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Kadiyska, Tanya ;Goranova, Teodora ;Dineva, Ganka ;Nedin, Dimitar ;Alexandrova,
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Article
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2006
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Walter de Gruyter GmbH
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English
β 131 KB
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, caused by germline mutations in DNA mismatch-repair genes (MMR). These mutations lead to microsatellite instability (MSI). It has been found that the MSI is not confined to the setting of hereditary disease and may