Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs
β Scribed by Ingrid H.C.H.M Philippens; Bert P.C Melchers; Berend Olivier; Piet L.B Bruijnzeel
- Book ID
- 114104326
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 150 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0091-3057
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
This study was designed to evaluate the prophylactic efficacy of transdermally administered physostigmine (PHY) against soman exposure using guinea-pigs. Transdermal PHY pad (3 cm2 kg-'; 60 p g cm-2), containing a vehicle based on propionic acid, was applied onto the dorsal back of the animals, 24 h
Current treatment of organophosphate poisoning is insufficient, and survivors may suffer from long-lasting adverse effects, such as cognitive deficits and sleep-wake disturbances. In the present study, we aimed at developing a guinea pig model to investigate the benefits of immediate and delayed sta