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Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

โœ Scribed by Li, X.

Book ID
124150598
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2005
Tongue
English
Weight
703 KB
Volume
280
Category
Article
ISSN
0021-9258

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## Abstract LDLโ€receptor related proteins 5 and 6 (LRP5/6) are coโ€receptors of Frizzled receptors that mediate Wntโ€induced activation of the transcription factor family TCF/LEFโ€1. Even though LRP5 and LRP6 are highly homologous, LRP6, but not LRP5, is expressed primarily in the nervous system and d