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Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6

✍ Scribed by Damien Fleury; Béatrice Vayssiere; Robert Touitou; Corinne Gillard; Hélène Lebhar; Georges Rawadi; Patrick Mollat

Book ID: 116829047
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 474 KB
Volume: 70
Category: Article
ISSN: 1046-5928
DOI: 10.1016/j.pep.2009.08.012

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## Background: Wnt/wingless (wg) signals are transduced by seven-transmembrane frizzleds (fzs) and the single-transmembrane ldl-receptor-related proteins 5 or 6 (lrp5/6) or arrow. the aminotermini of lrp and fz were reported to associate only in the presence of wnt, implying that wnt ligands form a