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Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone

✍ Scribed by Bart O Williams; Karl L Insogna


Book ID
111485688
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
568 KB
Volume
24
Category
Article
ISSN
0884-0431

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## Abstract LDL‐receptor related proteins 5 and 6 (LRP5/6) are co‐receptors of Frizzled receptors that mediate Wnt‐induced activation of the transcription factor family TCF/LEF‐1. Even though LRP5 and LRP6 are highly homologous, LRP6, but not LRP5, is expressed primarily in the nervous system and d