Scavenging of superoxide anion radical and hydroxyl radical by novel thiazolyl-thiazolidine-2,4-dione compounds

✍ Scribed by Oya Bozdağ-Dündar; Selen Gürkan; Hassan Y. Aboul-Enein; Irena Kruk; Aleksandra Kładna

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 394 KB
• Volume: 24
• Category: Article
• ISSN: 1522-7235
• DOI: 10.1002/bio.1095

✦ Synopsis

Abstract

The antioxidant behavior of a series of new synthesized substituted thiazolyl‐thiazolidine‐2,4‐dione compounds (TZDs) was examined using chemiluminescence and electron paramagnetic resonance spin trapping techniques. 5,5‐Dimethyl‐1‐pyrroline‐N‐oxide (DMPO) was used as the spin trap. The reactivity of TZDs with superoxide anion radical (O) and hydroxyl radical (HO^•^) was evaluated using potassium superoxide/18‐crown‐6 ether dissolved in dimethylsulfoxide, and the Fenton‐like reaction (Fe^2+^ + H~2~O~2~), respectively. The results showed that TZDs efficiently inhibited light emission from the O generating system at a concentration of 0.05–1 mmol L^−1^ (5–94% reductions were found at 1 mmol L^−1^ concentration). The TZD compounds showed inhibition of HO^•^‐dependent DMPO–OH spin adduct formation from DMPO (the amplitude decrease ranged from 8 to 82% at 1 mmol L^−1^ concentration). The findings showed that examined TZDs had effective activities as radical scavengers. Copyright © 2009 John Wiley & Sons, Ltd.