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Hydroxyl and superoxide radical scavenging abilities of chromonyl-thiazolidine-2,4-dione compounds

✍ Scribed by Irena Kruk; Oya Bozdağ-Dündar; Rahmiye Ertan; Hassan Y. Aboul-Enein; Teresa Michalska

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
266 KB
Volume
24
Category
Article
ISSN
1522-7235

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✦ Synopsis

Abstract

The oxygen free radical scavenging activities of 15 chromonyl‐thiazolidine‐2,4‐dione compounds (CTDs) were examined in chemical systems producing superoxide anion radicals, O (potasium superoxide–18‐crown‐6 ether–DMSO), and hydroxyl radicals, HO^•^ (a Fenton reaction: Fe(II)–H~2~O~2~–sodium trifluoroacetate, pH 6.15). Chemiluminescence and electron spin resonance (ESR) spectroscopy using 5,5‐dimethyl‐1‐pyrroline‐1‐oxide (DMPO) as spin trap were applied to evaluate antioxidant behaviour of CTDs towards the oxygen radicals. The results indicated that 11 of the 15 tested compounds showed a significant inhibitory effect on the chemiluminescence generated from the O‐generating system, ranging from 41 to 86%, and 13 CTDs quenched the ESR signal of the DMPO–OH spin adduct by 33–86%, at a concentration of 1 mmol L^−1^. Our findings demonstrate that CTDs could be good free radical scavengers. Copyright © 2008 John Wiley & Sons, Ltd.

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