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Sanguinarine-induced G1-phase arrest of the cell cycle results from increased p27KIP1 expression mediated via activation of the Ras/ERK signaling pathway in vascular smooth muscle cells

✍ Scribed by Beobyi Lee; Se-Jung Lee; Sung-Soo Park; Si-Kwan Kim; Sung-Ryong Kim; Jae-Hyun Jung; Wun-Jae Kim; Sung-Kwon Moon

Book ID: 116178094
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 592 KB
Volume: 471
Category: Article
ISSN: 0003-9861
DOI: 10.1016/j.abb.2008.01.008

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## Abstract The expression of matrix metalloproteinase‐9 (MMP‐9) has been implicated in progression of atherosclerotic lesions. The role and importance of the signaling pathway in the transcriptional regulation of MMP‐9 in human aortic smooth muscle cells (HASMC) was examined. Tumor necrosis factor