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Epigallocatechin-3-gallate causes the p21/WAF1-mediated G1-phase arrest of cell cycle and inhibits matrix metalloproteinase-9 expression in TNF-α-induced vascular smooth muscle cells

✍ Scribed by Cheorl-Ho Kim; Sung-Kwon Moon

Book ID: 116177259
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 512 KB
Volume: 435
Category: Article
ISSN: 0003-9861
DOI: 10.1016/j.abb.2004.12.022

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## Abstract The expression of matrix metalloproteinase‐9 (MMP‐9) has been implicated in progression of atherosclerotic lesions. The role and importance of the signaling pathway in the transcriptional regulation of MMP‐9 in human aortic smooth muscle cells (HASMC) was examined. Tumor necrosis factor