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Ras/ERK signaling pathway mediates activation of the p21WAF1 gene promoter in vascular smooth muscle cells by platelet-derived growth factor

✍ Scribed by Beobyi Lee; Sung-Kwon Moon

Book ID: 116177459
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 257 KB
Volume: 443
Category: Article
ISSN: 0003-9861
DOI: 10.1016/j.abb.2005.09.005

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## Abstract Smooth muscle cells (SMC) play a central role in common vascular pathologies such as atherosclerosis and restenosis. Understanding the molecular regulation of SMC proliferation at a transcriptional level may provide important clues for the targeted control of vascular hyperplasia. We re