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Samarium-mediated mild and facile method for the synthesis of amides

✍ Scribed by Feng Shi; Jian Li; Chunju Li; Xueshun Jia

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
177 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

Samarium-mediated facile method for the formation of amide bonds by the reaction of acyl chlorides and amines is described. The reaction afforded high yields of the desired amides under mild and neutral conditions.

πŸ“œ SIMILAR VOLUMES

Mild method for the synthesis of amidine
Mild method for the synthesis of amidines by the electrophilic activation of amides
✍ AndrΓ© B Charette; Michel Grenon πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 125 KB

The synthesis of amidines was achieved by the addition of amines to amides that were previously activated with trifluoromethanesulfonic anhydride (triflic anhydride) and pyridine. Various disubstituted and trisubstituted amidines were prepared in yields up to 84%.

ChemInform Abstract: Mild Method for the
ChemInform Abstract: Mild Method for the Synthesis of Thiazolines from Secondary and Tertiary Amides.
✍ A. B. CHARETTE; P. CHUA πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 31 KB πŸ‘ 2 views

Mild Method for the Synthesis of Thiazolines from Secondary and Tertiary Amides. -Base-promoted treatment of amides [cf. (I)] with triflic anhydride generates an iminium or imino triflate which reacts with an aminothiol directly to biologically interesting thiazolines. When optically pure cysteine